Article
Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.
Nature genetics - 1 Apr 2014
Gunawardana Jay, Chan Fong Chun, Telenius Adèle, Woolcock Bruce, Kridel Robert, Tan King L, Ben-Neriah Susana, Mottok Anja, Lim Raymond S, Boyle Merrill, Rogic Sanja, Rimsza Lisa M, Guiter Chrystelle, Leroy Karen, Gaulard Philippe, Haioun Corinne, Marra Marco A, Savage Kerry J, Connors Joseph M, Shah Sohrab P, Gascoyne Randy D, Steidl Christian
Abstract excerpt
Classical Hodgkin lymphoma and primary mediastinal B cell lymphoma (PMBCL) are related lymphomas sharing pathological, molecular and clinical characteristics. Here we discovered by whole-genome and whole-transcriptome sequencing recurrent somatic coding-sequence mutations in the PTPN1 gene. Mutations were found in 6 of 30 (20%) Hodgkin lymphoma cases, in 6 of 9 (67%) Hodgkin lymphoma-derived cell lines, in 17 of...
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