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Article

Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain.

Pain physician - 1 Jan 2013

Ehret Georg B, Daali Youssef, Chabert Jocelyne, Rebsamen Michela, Wolff Adriana, Forster Alain, Moursli Fouzia, Fritschy Daniel, Rossier Michel F, Piguet Valérie, Dayer Pierre, Gex-Fabry Marianne, Desmeules Jules A

Abstract excerpt

BACKGROUND: There is some evidence that dextromethorphan (DM) is effective as a pre-emptive analgesic agent. DM is mainly metabolized to dextrorphan (DOR) by CYP2D6 whose activity can be inhibited by pharmacologic intervention. OBJECTIVES: To investigate the efficacy of DM as a pre-emptive analge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23340533

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23340533-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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