Article
Contribution of cytochrome P-4502D6 phenotype to the neuromodulatory effects of dextromethorphan.
The Journal of pharmacology and experimental therapeutics - 1 Feb 1999
Desmeules J A, Oestreicher M K, Piguet V, Allaz A F, Dayer P
Abstract excerpt
Dextromethorphan (DEM)-mediated N-methyl-D-aspartate receptor blockade may result from an action of unchanged DEM or its active metabolite, dextrorphan (DOR). In humans, DEM is metabolized into DOR by the polymorphic enzyme CYP2D6. We therefore investigated the impact of quinidine (Qd), a selecti...
Topics
- Adult
- Cross-Over Studies
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP2D6 Inhibitors
- Dextromethorphan
- Enzyme Inhibitors
- Excitatory Amino Acid Antagonists
- Female
- Humans
- Hyperalgesia
- Male
- Neurotransmitter Agents
- Nociceptors
- Pain Threshold
- Phenotype
- Placebos
- Quinidine
- Tissue Distribution