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Article

Contribution of cytochrome P-4502D6 phenotype to the neuromodulatory effects of dextromethorphan.

The Journal of pharmacology and experimental therapeutics - 1 Feb 1999

Desmeules J A, Oestreicher M K, Piguet V, Allaz A F, Dayer P

Abstract excerpt

Dextromethorphan (DEM)-mediated N-methyl-D-aspartate receptor blockade may result from an action of unchanged DEM or its active metabolite, dextrorphan (DOR). In humans, DEM is metabolized into DOR by the polymorphic enzyme CYP2D6. We therefore investigated the impact of quinidine (Qd), a selective inhibitor of CYP2D6, on DEM disposition and the contribution of CYP2D6 phenotype on DEM antinociceptive and...

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PMID: 9918565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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