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Article

Npc1 gene mutation impairs multilineage differentiation potential of hepatic telocytes in murine models.

Cell biology and toxicology - 21 Apr 2025

Yang Jichao, Chang Yuqiao, Qiao Liang, Dama Ganesh, Lou Yongli, Lin Juntang

Abstract excerpt

OBJECTIVE: To investigate the effect of the Npc1 gene on the biological activity of Telocytes (TCs) in the liver and to provide theoretical support for further research on the biological activity of TCs. METHODS: Primary liver tissue cultures (TCs) from neonatal Npc1+/+ and Npc1-/- mice were extracted and cultured using an optimized type II collagenase-digestion protocol, and subsequently purified through a...

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Identifiers

PMID: 40257496
DOI: 10.1007/s10565-025-10018-6
PMCID: PMC12011650

Genes

NPC1
CD34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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