Article
Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2015
Cicchini Carla, Amicone Laura, Alonzi Tonino, Marchetti Alessandra, Mancone Carmine, Tripodi Marco
Abstract excerpt
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells. Only within a correct tissue organization, in fact, they stably maintain their identity and differentiated phenotype. The loss of histotype identity, which invariably occurs in the primary hepatocytes in culture, or in vivo in particular pathological...
Topics
- Epithelial-Mesenchymal Transition
- Gene Expression Regulation
- Hepatocyte Nuclear Factor 4
- Hepatocytes
- Humans
- MicroRNAs
- Models, Biological
- Phenotype
- Snail Family Transcription Factors
- Transcription Factors