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Article

Methylation of AR locus does not always reflect X chromosome inactivation state.

Blood - 29 Mar 2012

Swierczek Sabina I, Piterkova Lucie, Jelinek Jaroslav, Agarwal Neeraj, Hammoud Sue, Wilson Andrew, Hickman Kimberly, Parker Charles J, Cairns Bradley R, Cairns Bradley, Prchal Josef T

Abstract excerpt

Clonality can be established by a lack of mosaicism in a female because of random inactivation of either the maternal or paternal X chromosome early in embryogenesis. The methylation status of CpG sites close to the trinucleotide repeats in exon 1 of the human androgen receptor (AR) X chromosome gene assay (HUMARA) has been used to determine clonality. This HUMARA at times indicated clonal hematopoiesis in...

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Share to Chromosomes, Human, X
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Janus Kinase 2

Share to Myeloproliferative Disorders

Share to Receptors, Androgen

Share to Trinucleotide Repeats

Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 22286197
DOI: 10.1182/blood-2011-11-390351
PMCID: PMC3321879

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