SOCS3 Deletion in T Lymphocytes Suppresses Development of Chronic Ocular Inflammation via Upregulation of CTLA-4 and Expansion of Regulatory T Cells

Abstract excerpt

Suppressors of cytokine signaling (SOCS) proteins are negative-feedback regulators of the JAK/STAT pathway, and SOCS3 contributes to host immunity by regulating the intensity and duration of cytokine signals and inflammatory responses. Mice with Socs3 deletion in myeloid cells exhibit enhanced STAT3 signaling, expansion of Th1 and Th17 cells, and develop severe experimental autoimmune encephalomyelitis....

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