Article
Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012
Qin Hongwei, Yeh Wen-I, De Sarno Patrizia, Holdbrooks Andrew T, Liu Yudong, Muldowney Michelle T, Reynolds Stephanie L, Yanagisawa Lora L, Fox Thomas H, Park Keun, Harrington Laurie E, Raman Chander, Benveniste Etty N
Abstract excerpt
Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the JAK/STAT pathway. SOCS3 has a crucial role in inhibiting STAT3 activation, cytokine signaling, and inflammatory gene expression in macrophages/microglia. To determine the role of SOCS3 in myeloid cells in neuroinflammation, mice with conditional SOCS3 deletion in myeloid cells (LysMCre-SOCS3(fl/fl)) were tested for experimental...
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