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Article

Ascertainment biases in SNP chips affect measures of population divergence.

Molecular biology and evolution - 1 Nov 2010

Albrechtsen Anders, Nielsen Finn Cilius, Nielsen Rasmus

Abstract excerpt

Chip-based high-throughput genotyping has facilitated genome-wide studies of genetic diversity. Many studies have utilized these large data sets to make inferences about the demographic history of human populations using measures of genetic differentiation such as F(ST) or principal component analyses. However, the single nucleotide polymorphism (SNP) chip data suffer from ascertainment biases caused by the SNP...

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PMID: 20558595
DOI: 10.1093/molbev/msq148
PMCID: PMC3107607

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