Article

Conditional ATXN2L-Null in Adult Frontal Cortex CamK2a+ Neurons Does Not Cause Cell Death, but Restricts Spontaneous Mobility, and Affects the Alternative Splicing Pathway

2025-09-10

Abstract excerpt

Ataxin-2-like (ATXN2L) protein is required to survive embryonic development, as documented in mice with constitutive absence of ATXN2L Lsm, LsmAD and PAM2 domains, due to knockout (KO) of exons 5-8 with frameshift. Its less abundant paralog Ataxin-2 (ATXN2) has an extended N-terminus, where a polyglutamine domain is prone to expansions, which mediate vulnerability to the polygenic adult motor neuron disease ALS (A...

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Literature Corpus work: 6b37e387-5cc8-5bf0-9859-eaff72d9fa96
DOI: 10.20944/preprints202509.0886.v1

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Conditional ATXN2L-Null in Adult Frontal Cortex CamK2a+ Neurons Does Not Cause Cell Death, but Restricts Spontaneous Mobility, and Affects the Alternative Splicing PathwayDOI 10.20944/preprints202509.0886.v1Read

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