Article
Human class I major histocompatibility complex transgene prevents virus-induced demyelination in susceptible mutant B10.D2dml mice.
Annals of neurology - 1 Feb 1993
Rodriguez M, Pedrinaci S, David C S
Abstract excerpt
Theiler's murine encephalomyelitis virus (TMEV) induces immune-mediated demyelination in susceptible strains of mice, providing an excellent model for multiple sclerosis. Class I genes within the major histocompatibility complex locus (H-2D region) play a major role in determining whether strains...
Topics
- Animals
- Antigens, Viral
- Demyelinating Diseases
- Enterovirus Infections
- Genes
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-B27 Antigen
- Humans
- Maus Elberfeld virus
- Mice
- Mice, Neurologic Mutants
- Mice, Transgenic
- Microscopy, Electron
- Myelin Sheath
- Spinal Cord