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Article

SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients.

BMC endocrine disorders - 10 Aug 2023

AlEjielat Rowan, Khaleel Anas, Batarseh Yazan S, Abu-Qatouseh Luay, Al-Wawi Suzan, AlSunna Toleen

Abstract excerpt

BACKGROUND AND PURPOSE: Primary hypothyroidism due to abnormality in the thyroid gland is the most common endocrine disease The recommended starting dose of levothyroxine replacement therapy is 1.6 µg/kg. This dose however is not optimal for every patient and dose adjustments are frequently done. Genetic polymorphisms in the absorption and metabolism pathway of levothyroxine are likely to influence its dose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37563580
DOI: 10.1186/s12902-023-01425-z
PMCID: PMC10413766

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