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Article

M2 Macrophage-Derived Exosomes Inhibit Atherosclerosis Progression by Regulating the Proliferation, Migration, and Phenotypic Transformation of Smooth Muscle Cells.

Frontiers in bioscience (Landmark edition) - 19 Aug 2024

Wang Shuo, Wang Xiaokang, Lv Yunhui, Zhang Zhenhao, He Ting, Hao Xiaodong, Wang Shuang, Wang Chunqiang, Meng Jian, Zhong Kejia, Ye Zhen, Chen Tao, Cui Yongchun

Abstract excerpt

BACKGROUND: Vascular smooth muscle cell (VSMC) intimal migration, proliferation, and phenotypic transformation from a contractile to a synthetic state are hallmarks of the progression of atherosclerotic plaques. This study aims to explore the effects of exosomes derived from M2 macrophages (ExoM2) on the pathological changes of VSMCs in atherosclerosis (AS). METHODS: Cell Counting Kit-8 (CCK8) and wound healing...

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Share to Atherosclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Exosomes

Share to Macrophages

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Source

Identifiers

PMID: 39206919
DOI: 10.31083/j.fbl2908288

Genes

CD68
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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