Article
TSPAN4 controls vascular smooth muscle cell phenotypic switching and intimal hyperplasia by targeting TPM1-regulated cytoskeletal organization.
Clinical science (London, England : 1979) - 8 Oct 2025
Li Shengbiao, Chen Kexin, Zhang Yi, Yu Yang, Zhang Tianyi, Jiang Donghui, Li Mi, Fu Shubo, Chen Ji, Li Jiapan, Yi Jingyan, Li Rong, Qiao Gan, Feng Jianguo, Jiang Jun, Yuan Qiong, Zhang Chunxiang
Abstract excerpt
Vascular smooth muscle cell (VSMC) phenotypic switching, followed by enhanced proliferation and migration, is a key event in the development of intimal hyperplasia in diverse vascular diseases. While tetraspanin 4 (TSPAN4) is known to be expressed in the vasculature, its function in VSMC phenotypic switching and vascular disease is currently unknown. Here, we investigated the role of TSPAN4 using an in vitro...
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