Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma.

Oncotarget - 29 Mar 2016

Chen Ren-Hui, Du Yong, Han Ping, Wang Hong-Bo, Liang Fa-Ya, Feng Guo-Kai, Zhou Ai-Jun, Cai Mu-Yan, Zhong Qian, Zeng Mu-Sheng, Huang Xiao-Ming

Abstract excerpt

Interferon-stimulated gene 15 (ISG15), the first identified ubiquitin-like protein, is known for its anti-viral capacity. However, its role in tumorigenesis remains controversial. Here, using RNA-seq profiling analysis, we identified ISG15 as a differentially expressed gene in nasopharyngeal carcinoma (NPC) and validated its overexpression in NPC samples and cells. High ISG15 levels in NPC tissues were correlated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterografts

Share to Mice, Nude

Share to Nasopharyngeal Carcinoma

Share to Nasopharyngeal Neoplasms

Share to Neoplastic Stem Cells

Share to Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 26919245
DOI: 10.18632/oncotarget.7626
PMCID: PMC4941359

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma.PMID 26919245Read ↗

ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive systemSemantic proximity Read ↗

ISG15: A double edged sword in cancerSemantic proximity Read ↗

ISG15: A link between innate immune signaling, DNA replication, and genome stabilitySemantic proximity Read ↗

KIF15 Accelerated The Progression of Nasopharyngeal Carcinoma and Predict Poor PrognosisSemantic proximity Read ↗

ISG15 upregulation characterizes a PD-L1-associated immunosuppressive phenotype with CD8+ T-cell dysfunction in hepatocellular carcinoma.Semantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.Semantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune ResponseSemantic proximity Read ↗

Expression of ISG15 in colorectal cancer and exploration of its mechanism of actionSemantic proximity Read ↗

ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic Cancer Cells Through ATG7Semantic proximity Read ↗

The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.