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Article

Computational approaches for discovery of mutational signatures in cancer.

Briefings in bioinformatics - 18 Jan 2019

Baez-Ortega Adrian, Gori Kevin

Abstract excerpt

The accumulation of somatic mutations in a genome is the result of the activity of one or more mutagenic processes, each of which leaves its own imprint. The study of these DNA fingerprints, termed mutational signatures, holds important potential for furthering our understanding of the causes and evolution of cancer, and can provide insights of relevance for cancer prevention and treatment. In this review, we...

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PMID: 28968631
DOI: 10.1093/bib/bbx082
PMCID: PMC6357558

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