Article

Computational approaches for discovery of mutational signatures in cancer

2017-06-24

Abstract excerpt

The accumulation of somatic mutations in a genome is the result of the activity of one or more mutagenic processes, each of which leaves its own imprint. The study of these DNA fingerprints, termed mutational signatures, holds important potential for furthering our understanding of the causes and evolution of cancer, and can provide insights of relevance for cancer prevention and treatment. In this review, we focu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 409d8ed6-55c3-5e6e-9f2b-184d9f410e37
DOI: 10.1101/154716

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational approaches for discovery of mutational signatures in cancerDOI 10.1101/154716Read

Computational approaches for discovery of mutational signatures in cancer.Semantic proximity Read

Understanding mutagenesis through delineation of mutational signatures in human cancer.Semantic proximity Read

Computational tools to detect signatures of mutational processes in DNA from tumours: a review and empirical comparison of performanceSemantic proximity Read

Mechanisms underlying mutational signatures in human cancers.Semantic proximity Read

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes.Semantic proximity Read

Mutational Signatures: From Methods to Mechanisms.Semantic proximity Read

Mutational signatures: emerging concepts, caveats and clinical applications.Semantic proximity Read

Decomposing the mutational landscape of cancer genomes with RepairSig.Semantic proximity Read

Bioinformatic Methods to Identify Mutational Signatures in Cancer.Semantic proximity Read

Deciphering signatures of mutational processes operative in human cancer.Semantic proximity Read

Mutations, substitutions, and selection: Linking mutagenic processes to cancer using evolutionary theory.Semantic proximity Read

Genetics: Signatures of mutational processes in cancer-a big step closer.Semantic proximity Read