Article
Arginine metabolism and compensatory adaptations expand the impaired phage resistance repertoire in colistin-resistant Acinetobacter baumannii.
International journal of antimicrobial agents - 1 Oct 2026
Hao Jingchen, Xie Jun, Chen Xutao, Liu Cuicui, Guo Tingting, Zhang Pengyu, Li Xinrong, Ma Kangrong, Li Na, Hu Jian, Li Guocai
Abstract excerpt
OBJECTIVE: Limiting the emergence of phage resistance is a key priority in optimizing phage therapy. However, it remains poorly understood whether the development of antibiotic resistance influences the evolution of phage resistance. METHODS: To investigate phage-host interactions, we used both colistin-resistant strains derived from the wild-type and genetically engineered knockout mutants. Transcriptomic...
Read the complete abstract on PubMedTopics
- Acinetobacter baumannii
- Colistin
- Anti-Bacterial Agents
- Bacteriophages
- Arginine
- Drug Resistance, Bacterial