A functional insertion/deletion polymorphism (-94 ins/del ATTG) in the promoter region of the NFKB1 gene is related to the risk of renal cell carcinoma.

doi:10.1159/000345630

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Article

A functional insertion/deletion polymorphism (-94 ins/del ATTG) in the promoter region of the NFKB1 gene is related to the risk of renal cell carcinoma.

Urologia internationalis - 1 Jan 2013

Cai Hongzhou, Sun Lijiang, Cui Li, Cao Qiang, Qin Chao, Zhang Guiming, Mao Xin, Wang Meilin, Zhang Zhengdong, Shao Pengfei, Yin Changjun

Abstract excerpt

OBJECTIVE: Activated nuclear factor-ĸB is associated with the pathogenesis of numerous malignancies, including renal cell carcinoma (RCC). This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility. METHODS: We genotyped the NFKB1 -94 ins/del ATTG promoter polymorphism by the TaqMan method and assessed the...

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PMID: 23295440
DOI: 10.1159/000345630

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NFKB1

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