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Article

A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2009

Wang Meilin, Zhang Zhizhong, Tian Yuanyuan, Shao Jianfeng, Zhang Zhengdong

Abstract excerpt

PURPOSE: Caspase-8 (CASP8) is a key regulator of apoptosis or programmed cell death, an essential defense mechanism against hyperproliferation and malignancy. We hypothesized that the variants in the CASP8 gene are associated with risk of bladder cancer. EXPERIMENTAL DESIGN: In a hospital-based case-control study of 365 case patients with newly diagnosed bladder transitional cell carcinoma and 368 cancer-free...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19276244
DOI: 10.1158/1078-0432.CCR-08-2829

Genes

CASP8

Provenance

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