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Article

CASP8 -652 6N del polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis.

PloS one - 1 Jan 2014

Peng Qiliu, Lao Xianjun, Tang Weizhong, Chen Zhiping, Li Ruolin, Wang Jian, Deng Yan, Li Taijie, Qin Xue, Li Shan

Abstract excerpt

OBJECTIVE: Caspase-8 (CASP8) plays a central role in the apoptotic pathway and aberrant regulation of this pathway may cause cancers. Previous studies investigating the association between CASP8 -652 6N ins/del polymorphism and colorectal cancer (CRC) risk showed inconclusive results. We performed a meta-analysis of all available studies to investigate this association. METHODS: All studies published up to...

Topics

Case-Control Studies
Caspase 8
Colorectal Neoplasms
Gene Deletion
Genetic Predisposition to Disease
Humans
Polymorphism, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24498403
DOI: 10.1371/journal.pone.0087925
PMCID: PMC3912176

Genes

CASP8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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