Article
Association between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study.
PloS one - 1 Jan 2014
Pardini Barbara, Verderio Paolo, Pizzamiglio Sara, Nici Carmela, Maiorana Maria Valeria, Naccarati Alessio, Vodickova Ludmila, Vymetalkova Veronika, Veneroni Silvia, Daidone Maria Grazia, Ravagnani Fernando, Bianchi Tiziana, Bujanda Luis, Carracedo Angel, Castells Antoni, Ruiz-Ponte Clara, Morreau Hans, Howarth Kimberley, Jones Angela, Castellví-Bel Sergi, Li Li, Tomlinson Ian, Van Wezel Tom, Vodicka Pavel, Radice Paolo, Peterlongo Paolo
Abstract excerpt
The common -652 6N del variant in the CASP8 promoter (rs3834129) has been described as a putative low-penetrance risk factor for different cancer types. In particular, some studies suggested that the deleted allele (del) was inversely associated with CRC risk while other analyses failed to confirm this. Hence, to better understand the role of this variant in the risk of developing CRC, we performed a...
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