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Article

The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions.

Journal of clinical immunology - 1 Jul 2018

Rieux-Laucat Frédéric, Magérus-Chatinet Aude, Neven Bénédicte

Abstract excerpt

The autoimmune lymphoproliferative syndrome (ALPS) is a non-malignant and non-infectious uncontrolled proliferation of lymphocytes accompanied by autoimmune cytopenia. The genetic etiology of the ALPS was described in 1995 by the discovery of the FAS gene mutations. The related apoptosis defect accounts for the accumulation of autoreactive lymphocytes as well as for specific clinical and biological features that...

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Source

Identifiers

PMID: 29911256
DOI: 10.1007/s10875-018-0523-x

Genes

FAS
FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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