Immunologic evaluation and genetic defects of apoptosis in patients with autoimmune lymphoproliferative syndrome (ALPS).

doi:10.1080/10408363.2020.1855623

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Article

Immunologic evaluation and genetic defects of apoptosis in patients with autoimmune lymphoproliferative syndrome (ALPS).

Critical reviews in clinical laboratory sciences - 1 Jun 2021

Casamayor-Polo Laura, López-Nevado Marta, Paz-Artal Estela, Anel Alberto, Rieux-Laucat Frederic, Allende Luis M

Abstract excerpt

Apoptosis plays an important role in controlling the adaptive immune response and general homeostasis of the immune cells, and impaired apoptosis in the immune system results in autoimmunity and immune dysregulation. In the last 25 years, inherited human diseases of the Fas-FasL pathway have been recognized. Autoimmune lymphoproliferative syndrome (ALPS) is an inborn error of immunity, characterized clinically by...

Topics

Apoptosis
Autoimmune Diseases
Autoimmune Lymphoproliferative Syndrome
Humans
Mutation
Quality of Life
fas Receptor

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Open in PubMed

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PMID: 33356695
DOI: 10.1080/10408363.2020.1855623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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