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Article

Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning.

Developmental biology - 15 Mar 2013

Liu Jiang, Li Qiang, Kuehn Michael R, Litingtung Ying, Vokes Steven A, Chiang Chin

Abstract excerpt

Sonic hedgehog (Shh) signal, mediated by the Gli family of transcription factors, plays an essential role in the growth and patterning of the limb. Through analysis of the early limb bud transcriptome, we identified a posteriorly-enriched gene, Hyaluronic Acid Synthase 2 (Has2), which encodes a key enzyme for the synthesis of hyaluronan (HA), as a direct target of Gli transcriptional regulation during early mouse...

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Identifiers

PMID: 23313125
DOI: 10.1016/j.ydbio.2012.12.018
PMCID: PMC3820152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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