Article
Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease.
The Journal of biological chemistry - 1 Apr 2011
Wang Hongxia, Song Pingping, Du Lei, Tian Weili, Yue Wen, Liu Min, Li Dengwen, Wang Bin, Zhu Yushan, Cao Cheng, Zhou Jun, Chen Quan
Abstract excerpt
Mutations in Parkin, an E3 ubiquitin ligase that regulates protein turnover, represent one of the major causes of familial Parkinson disease, a neurodegenerative disorder characterized by the loss of dopaminergic neurons and impaired mitochondrial functions. The underlying mechanism by which pathogenic Parkin mutations induce mitochondrial abnormality is not fully understood. Here, we demonstrate that Parkin...
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