Article
Mapping of the IRF8 gene identifies a 3'UTR variant associated with risk of chronic lymphocytic leukemia but not other common non-Hodgkin lymphoma subtypes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2013
Slager Susan L, Achenbach Sara J, Asmann Yan W, Camp Nicola J, Rabe Kari G, Goldin Lynn R, Call Timothy G, Shanafelt Tait D, Kay Neil E, Cunningham Julie M, Wang Alice H, Weinberg J Brice, Norman Aaron D, Link Brian K, Leis Jose F, Vachon Celine M, Lanasa Mark C, Caporaso Neil E, Novak Anne J, Cerhan James R
Abstract excerpt
BACKGROUND: Our genome-wide association study (GWAS) of chronic lymphocytic leukemia (CLL) identified 4 highly correlated intronic variants within the IRF8 gene that were associated with CLL. These results were further supported by a recent meta-analysis of our GWAS with two other GWAS of CLL, supporting the IRF8 gene as a strong candidate for CLL risk. METHODS: To refine the genetic association of CLL risk, we...
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