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Article

Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis.

Arthritis research & therapy - 10 Jan 2013

Aida-Yasuoka Keiko, Peoples Christine, Yasuoka Hidekata, Hershberger Pamela, Thiel Katelynn, Cauley Jane A, Medsger Thomas A, Feghali-Bostwick Carol A

Abstract excerpt

INTRODUCTION: Systemic sclerosis (SSc) is more prevalent in women. Our goal is to determine the effects of 17β-estradiol (E2) on the development of fibrosis and to compare circulating levels of estrogens in SSc patients and healthy controls. METHODS: Using primary human dermal fibroblasts, we evaluated the effect of E2 on fibronectin (FN) expression with and without the estrogen receptor (ER) antagonist ICI...

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Identifiers

PMID: 23305385
DOI: 10.1186/ar4140
PMCID: PMC3672719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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