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Article

Interleukin-35 is upregulated in systemic sclerosis and its serum levels are associated with early disease

31 Jul 2015

Abstract excerpt

OBJECTIVES: IL-35 is a member of the IL-12 family consisting of p35/IL-12a and EBI3/IL-27b subunits. IL-35 exerts immunomodulatory activities in experimental and human autoimmune inflammatory conditions. Our aim was to assess IL-35 expression in the skin and circulation of SSc patients and to characterize its potential association with SSc-related features. METHODS: Expression of IL-35 in skin and dermal...

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PMID: 26231346
DOI: 10.1093/rheumatology/kev260

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