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Article

Low cyclin <scp>F</scp> expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis

10 Jan 2013

Abstract excerpt

Cyclin F, capable of forming Skp1-Cul1-F-box protein ubiquitin ligase complex, is implicated in controlling centrosome duplication and preventing genome instability. Cyclin F oscillates during cell cycle with a similar pattern to cyclin A. However, its expression and significance in cancer remain obscure. In this study, we showed that cyclin F was noticeably decreased in 16 pairs of tissue samples of...

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PMID: 23305207
DOI: 10.1111/cas.12100

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