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Article

Regulation of cyclin E protein levels through E2F-mediated inhibition of degradation.

Cell cycle (Georgetown, Tex.) - 1 Dec 2004

Pajalunga Deborah, Crescenzi Marco

Abstract excerpt

Cyclin E is a key cell cycle regulator, whose accumulation is believed to be positively modulated chiefly at the transcriptional level. We show that forced expression of E2F family members specifically stabilizes cyclin E protein by reducing its conjugation with ubiquitin, leading to increased steady-state levels. The stabilized protein shows enhanced association with cdk2 and higher kinase activity, indicating...

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Identifiers

PMID: 15611651
DOI: 10.4161/cc.3.12.1279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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