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Article

Analysis of Protein-Protein Interactions by Split Luciferase Complementation Assay.

Current protocols in toxicology - 1 Dec 2019

Lang Yuekun, Li Zhong, Li Hongmin

Abstract excerpt

Protein-protein interactions are important in human disease. Developing and refining tools to understand physical contacts between signaling proteins is crucial. This article describes a split luciferase complementation (SLC) method designed to discover inhibitors of protein-protein interaction. Different fusion proteins with split luciferase are constructed, expressed, and purified, and then assessed to...

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Identifiers

PMID: 31797579
DOI: 10.1002/cptx.90
PMCID: PMC7269092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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