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Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing mice

1 Jun 2022

Abstract excerpt

BACKGROUND: Intracellular deposition of alpha-synuclein (α-syn) as Lewy bodies and Lewy neurites is a central event in the pathogenesis of Parkinson's disease (PD) and other α-synucleinopathies. Transgenic mouse models overexpressing human α-syn, are useful research tools in preclinical studies of pathogenetic mechanisms. Such mice develop α-syn inclusions as well as neurodegeneration with a topographical...

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PMID: 35652155
DOI: 10.1002/brb3.2628

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