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Article

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.

Experimental neurology - 1 May 2002

Richfield Eric K, Thiruchelvam Mona J, Cory-Slechta Deborah A, Wuertzer Charles, Gainetdinov Raul R, Caron Marc G, Di Monte Donato A, Federoff Howard J

Abstract excerpt

Human alpha-synuclein (halpha-SYN) is implicated in the Parkinson's disease phenotype (PDP) based on a variety of studies in man, animal models, and in vitro studies. The normal function of halpha-SYN and the mechanism by which it contributes to the PDP remains unclear. We created transgenic mice expressing either wild-type (hwalpha-SYN) or a doubly mutated (hm2alpha-SYN) form of halpha-SYN under control of the...

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PMID: 12009758
DOI: 10.1006/exnr.2002.7882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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