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Article

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease.

Behavioural brain research - 26 Feb 2018

Frahm Silke, Melis Valeria, Horsley David, Rickard Janet E, Riedel Gernot, Fadda Paula, Scherma Maria, Harrington Charles R, Wischik Claude M, Theuring Franz, Schwab Karima

Abstract excerpt

Alpha-Synuclein (α-Syn) accumulation is considered a major risk factor for the development of synucleinopathies such as Parkinson's disease (PD) and dementia with Lewy bodies. We have generated mice overexpressing full-length human α-Syn fused to a membrane-targeting signal sequence under the control of the mouse Thy1-promotor. Three separate lines (L56, L58 and L62) with similar gene expression levels, but...

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Identifiers

PMID: 29180135
DOI: 10.1016/j.bbr.2017.11.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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