Article
Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease.
Inflammatory bowel diseases - 1 Oct 2017
Vancamelbeke Maaike, Vanuytsel Tim, Farré Ricard, Verstockt Sare, Ferrante Marc, Van Assche Gert, Rutgeerts Paul, Schuit Frans, Vermeire Séverine, Arijs Ingrid, Cleynen Isabelle
Abstract excerpt
BACKGROUND: Intestinal barrier defects are common in patients with inflammatory bowel disease (IBD). To identify which components could underlie these changes, we performed an in-depth analysis of epithelial barrier genes in IBD. METHODS: A set of 128 intestinal barrier genes was selected. Polygenic risk scores were generated based on selected barrier gene variants that were associated with Crohn's disease (CD)...
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