Article
A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations.
PloS one - 1 Jan 2012
Karakas Mahir, Baumert Jens, Kleber Marcus E, Thorand Barbara, Dallmeier Dhayana, Silbernagel Günther, Grammer Tanja B, Rottbauer Wolfgang, Meisinger Christa, Illig Thomas, März Winfried, Koenig Wolfgang
Abstract excerpt
BACKGROUND: Elevated soluble (s) E-selectin levels have been associated with various cardiovascular diseases. Recently, genetic variants in the ABO blood group have been related to E-selectin levels in a small cohort of patients with type 1 diabetes. We evaluated whether this association is repro...
Topics
- ABO Blood-Group System
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Animals
- Cardiovascular Diseases
- Disease Models, Animal
- E-Selectin
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype