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Article

Novel chimeras of botulinum and tetanus neurotoxins yield insights into their distinct sites of neuroparalysis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2012

Wang Jiafu, Zurawski Tomas H, Meng Jianghui, Lawrence Gary W, Aoki K Roger, Wheeler Larry, Dolly J Oliver

Abstract excerpt

Botulinum neurotoxin (BoNT) A or E and tetanus toxin (TeTx) bind to motor-nerve endings and undergo distinct trafficking; their light-chain (LC) proteases cleave soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) peripherally or centrally and cause flaccid or spastic paralysis, respectively. To seek protein domains responsible for local blockade of transmitter release (BoNTs) rather...

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Identifiers

PMID: 22942075
DOI: 10.1096/fj.12-210112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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