Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jul 2003

Li Shi-Hua, Yu Zhao-Xue, Li Cui-Lin, Nguyen Huu-Phuc, Zhou Yong-Xing, Deng Chuxia, Li Xiao-Jiang

Abstract excerpt

Huntington's disease (HD) is caused by a polyglutamine expansion in the disease protein huntingtin. The polyglutamine expansion causes huntingtin to interact abnormally with a number of proteins. However, it is unclear whether, and how, huntingtin-associated proteins are involved in the neurodegeneration in HD. Here, we show that huntingtin-associated protein-1 (HAP1), which is involved in intracellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Cell Death

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Feeding Behavior

Share to Gene Targeting

Share to Huntingtin Protein

Share to Huntington Disease

Share to Hypothalamus

Share to In Situ Nick-End Labeling

Source

Open in PubMed Open full text

Identifiers

PMID: 12890790
PMCID: PMC6740731

Genes

HAP1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.PMID 12890790Read ↗

Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation.Semantic proximity Read ↗

Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.Semantic proximity Read ↗

Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in miceSemantic proximity Read ↗

Immunohistochemical expression and neurochemical phenotypes of huntingtin-associated protein 1 in the myenteric plexus of mouse gastrointestinal tract.Semantic proximity Read ↗

Recent Advances in the Study of Huntingtin Interacting ProteinsSemantic proximity Read ↗

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form.Semantic proximity Read ↗

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.Semantic proximity Read ↗

Wild-type huntingtin plays a role in brain development and neuronal survival.Semantic proximity Read ↗

Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.Semantic proximity Read ↗

Recent advances in understanding the pathogenesis of Huntington's disease.Semantic proximity Read ↗

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.Semantic proximity Read ↗

Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.