Article
Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jul 2003
Li Shi-Hua, Yu Zhao-Xue, Li Cui-Lin, Nguyen Huu-Phuc, Zhou Yong-Xing, Deng Chuxia, Li Xiao-Jiang
Abstract excerpt
Huntington's disease (HD) is caused by a polyglutamine expansion in the disease protein huntingtin. The polyglutamine expansion causes huntingtin to interact abnormally with a number of proteins. However, it is unclear whether, and how, huntingtin-associated proteins are involved in the neurodegeneration in HD. Here, we show that huntingtin-associated protein-1 (HAP1), which is involved in intracellular...
Topics
- Animals
- Body Weight
- Cell Death
- Cell Survival
- Cells, Cultured
- Disease Models, Animal
- Disease Progression
- ErbB Receptors
- Feeding Behavior
- Fetal Viability