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Unraveling the Role of Huntingtin in Breast Cancer Metastasis

20 Aug 2015

Abstract excerpt

BACKGROUND: Huntingtin (HTT) is mutated in Huntington's disease but is ubiquitously expressed, and mutant HTT influences cancer progression. We investigated wild-type HTT function during breast cancer. METHODS: We analyzed HTT and ZO1 expression as well as the HTT phosphoserine 421-activated form (S421-P-HTT) in human breast cancer tissues by quantitative reverse transcription polymerase chain reaction and...

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PMID: 26293574
DOI: 10.1093/jnci/djv208

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