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Article

SMAD transcription factors are altered in cell models of HD and regulate HTT expression.

Cellular signalling - 1 Feb 2017

Bowles K R, Stone T, Holmans P, Allen N D, Dunnett S B, Jones L

Abstract excerpt

Transcriptional dysregulation is observable in multiple animal and cell models of Huntington's disease, as well as in human blood and post-mortem caudate. This contributes to HD pathogenesis, although the exact mechanism by which this occurs is unknown. We therefore utilised a dynamic model in order to determine the differential effect of growth factor stimulation on gene expression, to highlight potential...

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Source

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Identifiers

PMID: 27988204
DOI: 10.1016/j.cellsig.2016.12.005
PMCID: PMC5310119

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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