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Article

Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.

Journal of hepatology - 1 Nov 2012

Meng Zhipeng, Wang Xiaoqiong, Gan Yichao, Zhang Yunfeng, Zhou Hong, Ness Carl Van, Wu Jun, Lou Guiyu, Yu Hua, He Chao, Xu Rongzhen, Huang Wendong

Abstract excerpt

BACKGROUND & AIMS: Liver tumor, especially hepatocellular carcinoma (HCC), is closely associated with chronic inflammation. We previously showed that farnesoid X receptor knockout (FXR(-)(/)(-)) mice displayed chronic inflammation and developed spontaneous liver tumors when they aged. However, the mechanism by which inflammation leads to HCC in the absence of FXR is unclear. Because IFNγ is one of the most...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22728874
DOI: 10.1016/j.jhep.2012.06.016
PMCID: PMC3477276

Genes

STAT3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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