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Article

Regulation of Ligands for the NKG2D Activating Receptor

9 Jan 2013

Abstract excerpt

NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves as a major recognition receptor for detection and elimination of transformed and infected cells and participates in the genesis of several inflammatory diseases. The ligands for NKG2D are self-proteins that are induced by pathways that are active in certain pathophysiological states. NKG2D ligands are regulated...

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PMID: 23298206
DOI: 10.1146/annurev-immunol-032712-095951

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