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The Role and Regulation of the NKG2D/NKG2D Ligand System in Cancer

2 Aug 2023

Abstract excerpt

The family of human NKG2D ligands (NKG2DL) consists of eight stress-induced molecules. Over 80% of human cancers express these ligands on the surface of tumour cells and/or associated stromal elements. In mice, NKG2D deficiency increases susceptibility to some types of cancer, implicating this system in immune surveillance for malignancy. However, NKG2DL can also be shed, released via exosomes and trapped...

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PMID: 37626965
DOI: 10.3390/biology12081079

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