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Article

Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population.

PloS one - 1 Jan 2012

Grant Audrey V, Araujo Maria Ilma, Ponte Eduardo Vieira, Oliveira Ricardo Riccio, Gao Peisong, Cruz Alvaro A, Barnes Kathleen C, Beaty Terri H

Abstract excerpt

BACKGROUND: IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. METHODOLOGY/PRINCIPAL FINDINGS: Two functional polymorphisms in IL13, rs1800925 (or c.1-1111C>T) and rs20541 (or R130Q) were previously found to be associated with...

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Identifiers

PMID: 22574126
DOI: 10.1371/journal.pone.0035863
PMCID: PMC3345031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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