Article
Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population.
Immunogenetics - 1 Jul 2011
Hanel Susanne A, Velavan T P, Kremsner Peter G, Kun Jürgen F J
Abstract excerpt
Parasites exert a selection pressure on their hosts and are accountable for driving diversity within gene families and immune gene polymorphisms in a host population. The overwhelming response of regulatory T cells during infectious challenges directs the host immune system to lose the ability to mount parasite specific T cell responses. The underlying idea of this study is that regulatory single nucleotide...
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