Article

A short linear motif, conserved from yeast to human, binds to members of the Spa2/GIT1 family of cortical scaffold proteins

2025-06-17

Abstract excerpt

Tip growth is closely tied to fungal pathogenicity. Spa2, a multi-domain protein and member of the polarisome, orchestrates tip growth in yeast and other fungi. We identified a conserved short linear motif in the RabGAPs Msb3 and Msb4, and the MAP kinase kinase Ste7 and Mkk1, which mediates their interaction with Spa2. AlphaFold predictions suggest that these initially unstructured motifs adopt an alpha-helical co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 115939a8-5bc1-581b-95d1-c5d8b1bb4143
DOI: 10.1101/2025.06.12.659263

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A short linear motif, conserved from yeast to human, binds to members of the Spa2/GIT1 family of cortical scaffold proteinsDOI 10.1101/2025.06.12.659263Read

STRIPAK, a Key Regulator of Fungal Development, Operates as a Multifunctional Signaling HubSemantic proximity Read

A homologue of the human STRIPAK complex controls sexual development in fungiSemantic proximity Read

The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes.Semantic proximity Read

The STRIPAK signaling complex regulates phosphorylation of GUL1, an RNA-binding protein that shuttles on endosomesSemantic proximity Read

Distinct STRIPAK subunits drive conserved and subunit-specific signaling programs in <i>Cryptococcus neoformans</i>Semantic proximity Read

The punctate localisation of the yeast sterol transporter Ysp2p is determined by three dimerisation interfaces in its C-terminusSemantic proximity Read

Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.Semantic proximity Read

Deletion of Smgpi1 encoding a GPI-anchored protein suppresses sterility of the STRIPAK mutant ΔSmmob3 in the filamentous ascomycete Sordaria macrospora.Semantic proximity Read

New Features Surrounding the Cdc42-Ste20 Module that Regulates MAP Kinase Signaling in YeastSemantic proximity Read

Phosphoproteomic analysis of STRIPAK mutants identifies a conserved serine phosphorylation site in PAK kinase CLA4 to be important in fungal sexual development and polarized growthSemantic proximity Read

A small conserved domain in the yeast Spa2p is necessary and sufficient for its polarized localization.Semantic proximity Read

Stable Pseudohyphal Growth in Budding Yeast Induced by Synergism between Septin Defects and Altered MAP-kinase Signaling.Semantic proximity Read