Article
Longitudinal changes in CD4(+) T-cell memory responses induced by BCG vaccination of newborns.
The Journal of infectious diseases - 1 Apr 2013
Soares Andreia P, Kwong Chung Cheong K C, Choice Terry, Hughes E Jane, Jacobs Gail, van Rensburg Esme Janse, Khomba Gloria, de Kock Marwou, Lerumo Lesedi, Makhethe Lebohang, Maneli Mbulelo H, Pienaar Bernadette, Smit Erica, Tena-Coki Nontobeko G, van Wyk Leandre, Boom W Henry, Kaplan Gilla, Scriba Thomas J, Hanekom Willem A
Abstract excerpt
BACKGROUND: Improved vaccination strategies against tuberculosis are needed, such as approaches to boost immunity induced by the current vaccine, BCG. Design of these strategies has been hampered by a lack of knowledge of the kinetics of the human host response induced by neonatal BCG vaccination. Furthermore, the functional and phenotypic attributes of BCG-induced long-lived memory T-cell responses remain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.