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Article

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

1 Nov 2020

Abstract excerpt

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies have revealed that the induction of trained immunity is associated with a bias toward granulopoiesis in bone marrow hematopoietic progenitor cells, but it is...

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PMID: 33207187
DOI: 10.1016/j.celrep.2020.108387

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