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Article

Adolescent BCG revaccination induces a phenotypic shift in CD4+ T cell responses to Mycobacterium tuberculosis.

Nature communications - 18 Jun 2024

Dintwe One B, Ballweber Fleming Lamar, Voillet Valentin, McNevin John, Seese Aaron, Naidoo Anneta, Omarjee Saleha, Bekker Linda-Gail, Kublin James G, De Rosa Stephen C, Newell Evan W, Fiore-Gartland Andrew, Andersen-Nissen Erica, McElrath M Juliana

Abstract excerpt

A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M.tb). In a companion phase 1b trial, HVTN 602/Aeras A-042, we characterize in-depth the cellular responses to BCG revaccination or to a H4:IC31 vaccine boost to identify T cell subsets that could be responsible for the protection observed....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38890283
DOI: 10.1038/s41467-024-49050-1
PMCID: PMC11189459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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